|
CD1 |
an
MHC-like molecule that presents lipid
molecules |
|
CD2 |
a type I transmembrane protein found on
thymocytes, T cells, and some natural killer
cells that acts as a ligand for CD58 and CD59
and is involved in signal transduction and cell
adhesion; expressed in T-cell acute
lymphoblastic leukemia and T-cell lymphoma. |
|
CD3 |
the signaling component of the
T cell receptor (TCR) complex |
|
CD4 |
a co-receptor for MHC Class II; also a
receptor used by HIV to enter T cells |
|
CD5 |
a type I transmembrane protein found on T
cells, thymocytes, and some B cells that is a
ligand for CD72 and is involved in cellular
activation or adhesion; expressed in B-cell
chronic lymphocytic leukemia and T-cell
lymphoma. |
|
CD6 |
adhesion molecule linking developing
thymus-cells to thymus epithelial cells;
co-stimulator to mature T cells |
|
CD7 |
a type I transmembrane protein found on
thymocytes, some T cells, monocytes, natural
killer cells, and hemopoietic stem cells;
expressed in patients with mycosis fungoides,
some patients with T-cell acute lymphoblastic
lymphoma, and a few patients with acute
nonlymphocytic lymphoma. |
|
CD8 |
a co-receptor for MHC Class I; also found on
a subset of myeloid dendritic cells. |
|
CD9 |
a member of the
Tetraspanin superfamily expressed in a
variety of cells, including: pre
B cells,
eosinophils,
basophils and
platelets. |
|
CD10 |
a type II transmembrane protein found on
pre-B cells, germinal-center B cells, some
neutrophils, kidney cells, T-cell precursors,
and epithelial cells that acts as a zinc
metalloprotease cleaving peptide bonds on the
amino side of hydrophobic amino acids; expressed
in acute lymphocytic leukemia and
follicular-center-cell lymphomas. |
|
CD11a |
Subunit of
LFA-1, a membrane glycoprotein that provides
cell-cell adhesion by interaction with
ICAM-1 |
|
CD11b |
Subunit of
Mac-1, a complement receptor ("CR3")
consisting of
CD11b and
CD18. |
|
CD11c |
a type I transmembrane protein found on
monocytes, macrophages, neutrophils, and some B
cells that induces cellular activation and helps
trigger neutrophil respiratory burst; expressed
in hairy cell leukemias, acute nonlymphocytic
leukemias, and some B-cell chronic lymphocytic
leukemias. Also one of the defining markers for
dendritic cells. |
|
CD12w |
unknown |
|
CD13 |
a zinc metalloproteinase, also known as
aminopeptidase N, which is found naturally on
myelomonocytic cells from early differentiation
through maturity; usually present on
acute myeloid leukemia blasts and rarely
found in some forms of
lymphoma and lymphocytic leukemia |
|
CD14 |
a membrane protein found on
macrophages which binds to bacterial
lipopolysaccharide. |
|
CD15 |
a carbohydrate adhesion molecule (not a
protein) that mediates phagocytosis and
chemotaxis, found on neutrophils; expressed in
patients with Hodgkin disease, some B-cell
chronic lymphocytic leukemias, acute
lymphoblastic leukemias, and most acute
nonlymphocytic leukemias. It is also called
Lewis x and SSEA-1 (stage specific embryonic
antigen 1) and represents a marker for murine
pluripotent stem cells, in which it plays an
important role in adhesion and migration of the
cells in the preimplantation embryo. |
|
CD16 |
FcγRIII, a low-affinity Fc receptor for IgG.
Found on NK cells, macrophages, and neutrophils. |
|
CDw17 |
possible role in phagocytosis. Bacteria
binding. |
|
CD18 |
adhesion and signaling in the hematopoietic
system. |
|
CD19 |
B-lymphocyte surface antigen B4 |
|
CD20 |
a type III transmembrane protein found on B
cells that forms a calcium channel in the cell
membrane allowing for the influx of calcium
required for cell activation; expressed in
B-cell lymphomas, hairy cell leukemia, and
B-cell chronic lymphocytic leukemia. Important
for therapy of those diseases, as an antibody
against CD20 exists:
Rituximab |
|
CD21 |
a type I transmembrane protein found on B
cells, follicular dendritic cells, pharyngeal
and cervical epithelial cells, some thymocytes,
and some T cells that plays a role in signal
transduction; expressed in hairy cell leukemia,
B-cell lymphoma, and some T-cell acute
lymphocytic leukemias. |
|
CD21 |
CR2, a type I transmembrane protein found in
the cytoplasm of pre-B cells and on the surface
of mature B cells that facilitates signal
transduction; expressed in patients with hairy
cell leukemias and in some with B-cell
lymphomas. Receptor for complement (C3d) and
Epstein-Barr virus (EBV). |
|
CD22 |
a sugar binding transmembrane protein that
specifically binds sialic acid with an
immunoglobulin (Ig) domain located at its
N-terminus. It is a member of the
immunoglobulin superfamily and the
SIGLEC family. CD22 functions as an
inhibitory receptor for B cell receptor (BCR)
signalling. |
|
CD23 |
a type II transmembrane protein found on
mature B cells, monocytes, activated
macrophages, eosinophils, platelets, and
dendritic cells that enhances capture and
processing of antigen complexed with IgE. |
|
CD24 |
a glycoprotein expressed at the surface of
most B lymphocytes and differentiating
neuroblasts. This gene encodes a
sialoglycoprotein that is expressed on mature
granulocytes and in many B cells. The encoded
protein is anchored via a glycosyl
phosphatidylinositol (GPI) link to the cell
surface. An alignment of this gene's sequence
finds genomic locations with similarity on
chromosomes 3p26, 15q21, 15q22, 20q11.2 and
Yq11.1. Whether transcription, and corresponding
translation, occurs at each of these other
genomic locations needs to be experimentally
determined (source: NCBI). Is also known as Heat
Stable Antigen (HSA). |
|
CD25 |
a type I transmembrane protein present on
activated T cells, activated B cells, some
thymocytes, myeloid precursors, and
oligodendrocytes that associates with CD122 to
form a heterodimer that can act as a
high-affinity receptor for IL-2; expressed in
most B-cell neoplasms, some acute nonlymphocytic
leukemias, and neuroblastomas. |
|
CD26 |
Membrane-bound protease. T-cell
costimulatory molecule. Cell adhesion molecule |
|
CD27 |
TNF-receptor. Present on the surface of
resting memory B cells. |
|
CD28 |
present on all T-cells, and when matched
with the appropriate ligand, labeled B7 which
can be either CD80 or CD86, it has
costimulatory effect on the T-cell. It is
also expressed on
Eosinophil granulocytes, especially after
tissue infiltration. There its ligation leads to
release of potent neurotoxins, IL-2 and IL-13 as
well as IFN-γ |
|
CD29 |
AKA integrin beta-1 - a cell adhesion
molecule. |
|
CD30 |
a type I transmembrane protein present on
activated T and B cells that may play a role in
cell activation and/or differentiation;
expressed in Hodgkin disease, some T-cell
lymphomas, and anaplastic large cell lymphomas. |
|
CD31 |
PECAM-1, a
cell adhesion molecule on
platelets and
endothelial cells |
|
CD32 |
FcγRII, a receptor for the Fc (constant)
region of immunoglobulin G (IgG) |
|
CD33 |
a marker of unknown function found on
immature myeloid cells, including
acute myeloid leukemia blasts and mature
monocytes |
|
CD34 |
stem cell marker,
adhesion, found on
hematopoietic precursors (found in high
concentrations in
umbilical cord blood),
capillary
endothelium, and
embryonic
fibroblasts |
|
CD35 |
Complement receptor 1 (C3b/C4b receptor) |
|
CD36 |
Platelet glycoprotein IV or IIIb (GP IV / GP
IIIb) |
|
CD37 |
A
leucocyte restricted
tetraspanin expressed primarily in
B cells, but also found on
T cells,
Monocytes and
Granulocytes. |
|
CD38 |
involved in ecto-ADP-ribosyl
cyclase and cell activation on many
hematopoietic,
plasma, and
B &
T activated cells; marker increases with HIV
seroconversion, coexpression with CD8 associated
with progression (indicates persistent viral
stimulation) |
|
CD40 |
a costimulatory protein found on antigen
presenting cells. CD40 combines with
CD154 (CD40L) on T cells to induce antibody
isotype switching in B cells. |
|
CD41 |
The platelet glycoprotein
(GPIIb/IIIa) integrin acts as a receptor for
fibrinogen and several other extracellular
matrix molecules. Its absence causes an
extremely rare disorder of the blood known as
Glanzmann's thrombasthenia. |
|
CD42 |
the platelet Glycoprotein Ib/V/IX complex(GPIb/V/IX).
Expressed on platelets and is a late, specific
marker of megakaryocyte differentiation. The
Glycoprotein Ib/V/IX complex is essential for
normal haemostasis; deficiency results in
Bernard-Soulier Syndrome, a syndrome of
thrombocytopenia and giant platelets. |
|
CD43 |
CD43 is a sialomucin. |
|
CD44 |
A family of matrix adhesion molecules formed
by alternative mRNA splicing, that adhere to
hyaluronate, collagen, laminin, and fibronectin.
Helps maintain polarization of epithelial cells.
Found on bone marrow stromal cells and many
other cells. |
|
CD45 |
leucocyte common antigen, a type I
transmembrane protein present on all hemopoietic
cells except erythrocytes that assists in cell
activation; expressed in lymphomas, B-cell
chronic lymphocytic leukemia, hairy cell
leukemia, and acute nonlymphocytic leukemia. |
|
CD46 |
Inhibitory complement receptor which is
ubiquitously expressed on human cells. |
|
CD47 |
Membrane protein, which is involved in the
increase in intracellular calcium concentration
that occurs upon cell adhesion to extracellular
matrix. |
|
CD48 |
CD48 is a human protein encoded by the CD48
gene. |
|
CD49b |
Very late antigen (VLA) alpha 2 chain; found
on platelets and activated B and T cells. |
|
CD49c |
Very late antigen (VLA) alpha 3 chain; found
on nonhematopoietic bone marrow cells. Receptor
for collagen, laminin, fibronectin, and
thrombospondin. |
|
CD53 |
A
leucocyte restricted
tetraspanin expressed by
B cells,
T cells,
dendritic cells,
monocytes,
NK cells and
Granulocytes. |
|
CD54 |
Intercellular adhesion molecule -1 (ICAM-1):
facilitates adhesion between leukocytes to
endothelial cells during the immune and
inflammatory responses |
|
CD55 |
Complement Decay-Accelerating Factor (DAF):
regulatory factor in one of the three pathways
of the immune system complement cascade |
|
CD56 |
NCAM (neural cell adhesion molecule), a
marker for
natural killer cells and some T-lymphocytes |
|
CD58 |
a membrane protein present on many
hemopoietic cells and fibroblasts that acts as a
ligand for CD2 and may be involved in T-cell
function. |
|
CD59 |
Membrane attack complex inhibition factor
(MACIF); MAC-inhibitory protein (MAC-IP);
Antigen MEM43; Protectin: Immune system
complement cascade regulatory factor |
|
CD61 |
Integrin beta 3 (Itgb3); Glycoprotein IIIa
(GPIIIa):
fibrinogen receptor; major role is in
platelet aggregation.[1]
Defects in Itgb3 are causative for
Glanzmann's thrombasthenia. |
|
CD62E |
E-selectin is a cell adhesion molecule
expressed only on endothelial cells activated by
cytokines. |
|
CD62L |
L-selectin is a cell adhesion molecule found
on leukocytes. |
|
CD62P |
P-selectin is a cell adhesion molecule (CAM)
found in granules in endothelial cells (cells
lining blood vessels) and activated platelets. |
|
CD63 |
Member of the
Tetraspanin family expressed in activated
platelets,
monocytes and
macrophages. |
|
CD68 |
110 kDa highly glycosylated transmembrane
protein which is mainly located in lysosomes.
Present in macrophages in many human tissues
including Kupffer’s cells and macrophages in the
red pulp of the spleen, in lung alveoli, in
lamina propria of the gut, and in the bone
marrow. Used as immunocytochemical marker for
staining of monocytes/macrophages. |
|
CD69 |
An early activation marker on T cells and NK
cells. |
|
CD71 |
Transferrin receptor, mediates cellular
uptake of
iron |
|
CD72 |
Mediator of B-cell - T-cell interactions |
|
CD80 |
when bound to CD28 on T-cells, can provide
the costimulatory effect; also referred to as
B7.1, one of the
B7 molecules. Causes up-regulation of a high
affinity IL-2 receptor allowing T cells to
proliferate. |
|
CD81 |
A
tetraspanin expressed in a wide variety of
tissues, which plays an important role in
B cells as part of the
B cell co-receptor complex with CD19, Leu 13
and CD21. Also expressed in
T cells,
NK cells,
Dendritic cells,
Monocytes and blood progenitors. |
|
CD82 |
Member of the
tetraspanin family of transmembrane
proteins. Broad tissue distribution including
B cells,
T cells,
Granulocytes,
Monocytes and
CD34+ progenitors. |
|
CD83 |
a 45 kDa transmembrane glycoprotein of the
Ig superfamily. Expressed on cultured dendritic
cells, interdigitating, follicular, and
circulating dendritic cells as well as some
proliferating lymphocyte of all human cell
lines. Functionally unclear, but can serve as a
useful marker for mature human blood dendritic
cells. |
|
CD86 |
when bound to CD28 on T-cells, can provide
the costimulatory effect; also referred to as
B7.2, one of the
B7 molecules. Causes up-regulation of a high
affinity IL-2 receptor allowing T cells to
proliferate. |
|
CD87 |
also referred to as the urokinase type
plasminogen activator receptor, provides a
binding point for urokinase type plasminogen
activator |
|
CD88 |
C5a receptor |
|
CD89 |
FcalphaRI - receptor for IgA |
|
CD90 |
Thy-1 Thymus cell antigen. |
|
CD91 |
Low density lipoprotein (LDL)
receptor-related protein 1 (LRP1) (also known as
α2-macroglobulin receptor), a major endocytotic
receptor with over 35 known ligands including
amyloid precursor protein (APP), ApoE, and many
proteins involved with protease regulation |
|
CD95 |
Fas Receptor- receptor for Fas ligand, an
extrinsic apoptotic signal |
|
CD103 |
a type I transmembrane protein present on
intestinal intraepithelial lymphocytes, some
circulating leukocytes, and some T cells that
facilitates adhesion to epithelia; expressed in
hairy cell leukemia and some B-cell chronic
lymphocytic leukemias. |
|
CD105 |
Endoglin, a regulatory component of the
TGF-beta receptor-cell complex. Mediates
cellular response to TGFbeta. |
|
CD106 |
VCAM-1; Alpha 4 beta 1 ligand. Adhesion
molecule involved in white blood cell migration. |
|
CD109 |
r150, Gov alloantigen, an accessory receptor
of the TGF-beta signaling pathway. Mediates
cellular response to TGFbeta. Presents Gov
alloantigens and ABH blood antigens. |
|
CD117 |
c-kit, the
receptor for Stem Cell Factor, a
glycoprotein that regulates
cellular differentiation, particularly in
hematopoiesis |
|
CD120 |
a receptor for
Tumour Necrosis Factor, an inflammatory
cytokine |
|
CD127 |
the IL-7 receptor alpha chain |
|
CD133 |
a hematopoietic and CNS stem cell marker. A
5 transmembrane domain protein, with no known
function. Also known as AC133. |
|
CD134 |
Also known as OX40; A T cell secondary
costimulatory molecule which enances
proliferation, cytokine production and survival. |
|
CD135 |
Also known as fms-like tyrosine kinase
receptor-3 (Flt3) or fetal liver kinase-2
(Flk2); A
cytokine receptor for Flt3 ligand (Flt3L)
important in early
hematopoiesis. |
|
CD138 |
a plasma cell-surface
glycoprotein, known as syndecan-1. Syndecan
functions as the alpha receptor for collagen,
fibronectin and thrombospondin. |
|
CD141 |
Thrombomodulin or BDCA-3, an
integral membrane protein. On
endothelial cells, it is involved in
anticoagulation. It also occurs, with
unknown function, on a very rare subtype of
dendritic cells. |
|
CD142 |
Tissue factor, a major initiator of
blood-clotting |
|
CD143 |
Angiotensin-converting enzyme |
|
CD144 |
VE-Cadherin, a calcium-dependent adhesion
molecule at intercellular junctions, found
mainly in the vascular
endothelium. Recent research indicates that
CD144 may be present on some
leucocytes as well. |
|
CD147 |
Neurothelin. An extracellular matrix
metalloproteinase inducer. |
|
CD151 |
Tetraspanin with a wide tissue distribution,
including platelets, Megakaryocytes,
Granulocytes and erythroleukemia. |
|
CD152 |
Also called Cytotoxic T-lymphocyte antigen-4
(CTLA-4).
Expressed in
CD4+ T Lymphocytes but also found in some B
Lymphocytes. Binds to
CD80 and
CD86 receptors with a higher affinity than
CD28, and inhibits T cell activation. |
|
CD154 |
The ligand for CD40. This is a costimulatory
molecule that plays many roles, best known for
activating B cells but also known to induce the
activation of an APC in association with T cell
receptor stimulation by MHC molecules on the
APC. |
|
CD163 |
M130; HbSR; RM3/1 antigen. A glycoprotein
endocytic scavenger receptor for
haptoglobin-hemoglobin complexes. Found
specifically on monocytes/macrophages and some
dendritic cells. Involved in anti-iflammatory
processes. Soluble form shed upon Toll-like
receptor activation. |
|
CD166 |
activated leukocyte cell adhesion molecule
(ALCAM). |
|
CD168 |
receptor for hyaluronan-mediated motility
(RHAMM). |
|
CD184 |
CXCR4, Stromal Derived Factor 1 (SDF1).
Receptor for the CXC chemokine SDF1. A receptor
involved in mesenchymal stem cell homing and
migration. |
|
CDw186 |
CXCR6, a
G-protein-coupled receptor for the
chemokine CXCL16 |
|
CD209 |
DC-SIGN, C-type
lectin receptor found on dendritic cell
subsets |
|
CD202a |
Tie2, the receptor for angiopoietins, a
family of
angiogenic factors |
|
CD235a |
Glycophorin, a
protein on
blood
cells |
|
CD271 |
is the p75 Nerve Growth factor receptor
(NGFR) |
|
CD303 |
BDCA-2, a type II
transmembrane C-type
lectin which is involved in
endocytosis of
antigens for
processing in
plasmacytoid dendritic cells. Activation
decreases type I
interferon production. |
|
CD304 |
Neuropilin-1 (NP-1) or BDCA-4, has a wide
range of functions. On
neurons, it is a receptor for
axon growth guidance class-3
semaphorins SEMA3A and plexin-1, on
endothelial and some
tumor cells it is a
VEGF165 receptor, and on
plasmacytoid dendritic cells it has a
similar role to CD303 but does not decrease
interferon production upon activation. |
